Dr. Calum MacAulay is currently the Head of the Integrative Oncology Department at the British Columbia Cancer Research Centre (BC Cancer Agency). His group’s motivation is development and translation of technology from basic research into clinically applied procedures. His work focuses on the detection and imaging of early cancers at both the macroscopic and microscopic level using light and its interaction with cells and tissue. He has placed a particular emphasis on cancers of the lung, oral cavity, cervix and prostate. His research interests include the screening and detection of early cancers and the modeling of cancerous processes at multiple space scales (i.e. from the level of individual proteins within cells to the level of an entire region of tissue). He has worked to develop and optimize many types of technology in order to undertake his work (e.g. reflectance and fluorescence spectroscopy, reflectance and fluorescence imaging, confocal microendoscopy, optical coherence tomography, automated image cytometry, quantitative image pathology in absorption and fluorescence microscopy, and high resolution genomic profiling ) much of which have found their way in to clinically used devices. Some of these devices are already effecting patient outcomes.
Highlights of Dr. MacAulay’s research include his role in bringing the following technologies through invention stages to clinical application: the LIFE device for early lung cancer detection; the VELscope and the Identify for oral cancer/pre-cancer screening, detection, and tumour delineation; and an automated image cytometry approach for lung, oral and cervical cancer screening. All of these approaches are being used clinically in Canada, the US, China, and elsewhere around the world.
Lab website: https://www.bccrc.ca/dept/io/people/calum-macaulay