My research interests span several areas that link my clinical practice with research initiatives. My research activity focuses on developing new, improved treatment options for persons with breast cancer, lung cancer, HIV malignancies and other malignancies and spans Phase I, II, and III clinical trials in single centre and multicentre cooperative arenas, as well as research to understand the character of cancer and its effect on patients.
We have successfully taken liposomal vincristine through its intial preclinical development, into a IND approved by the Health Protection Branch and through one Phase I and two Phase II clinical trials. I am also involved in the development of another standard cytotoxic, anhydrovinblastine, which has been through preclinical testing and should enter clinical Phase 1 testing at the BCCA in l998. With other local companies we are exploring other options for anticancer therapy which may result in agents with novel mechanisms. This includes cationic fusion peptides which in the preclinical cell culture studies look active and promising, antisense strategies with bCL-2, ribosome technology against for example VEGF, modifiers of drug resistance, and other avenues of inhibiting cell growth. We will be testing many natural products which may be used in complementary medicine but may have potential if proven active in standard testing.
Lab website: https://medicine.med.ubc.ca/profiles/karen-a-gelmon/